The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 18, 2020

Filed:

Oct. 22, 2018
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

An-Suei Yang, Emeryville, CA (US);

Wei-Ying Kuo, Taipei, TW;

Hung-Ju Hsu, Taipei, TW;

Hong-Sen Chen, Taipei, TW;

Yu-Chi Chou, Taipei, TW;

Yueh-Liang Tsou, Taipei, TW;

Hung-Pin Peng, Taipei, TW;

Jhih-Wei Jian, Taipei, TW;

Chung-Ming Yu, Taipei, TW;

Yi-Kai Chiu, Taipei, TW;

Ing-Chein Chen, Taipei, TW;

Chao-Ping Tung, Taipei, TW;

Michael Hsiao, Taipei, TW;

Hwei-Jiung Wang, Taipei, TW;

Assignee:

Academia Sinica, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/38 (2006.01); A61K 39/395 (2006.01); C07K 16/30 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3015 (2013.01); A61K 39/39558 (2013.01); A61K 47/6829 (2017.08); A61K 47/6855 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract

Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.


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