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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10562954 B1

PDFFull Text
Date of Patent:
Feb. 18, 2020

Filed:

May. 12, 2014

Fusion protein inhibiting taci-baff complex formation and preparation method therefor and use thereof

Applicants:

Shanghai Kanda Biotechnology Co., Ltd., Shanghai, CN;

Shanghai Celgen Bio-pharmaceutical Co., Ltd., Shanghai, CN;

Inventors:

Zeling Cai, Shanghai, CN;

Yi Chen, Shanghai, CN;

Heng Wu, Shanghai, CN;

Guobo Fang, Shanghai, CN;

Assignees:

Shanghai Kanda Biotechnology Co., Ltd., Shanghai, CN;

Shanghai Celgen Bio-Pharmaceutical Co., Ltd., Shanghai, CN;

Attorney:

Wolf, Greenfield & Sack, P.C.

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/715 (2006.01); C07K 14/735 (2006.01); A61K 38/17 (2006.01); C12N 15/63 (2006.01); C12P 21/02 (2006.01); C07K 19/00 (2006.01); C07K 16/00 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70578 (2013.01); A61K 38/179 (2013.01); A61K 38/1774 (2013.01); A61K 38/1793 (2013.01); C07K 14/70535 (2013.01); C07K 14/70596 (2013.01); C07K 14/7151 (2013.01); C07K 16/00 (2013.01); C07K 19/00 (2013.01); C12N 15/63 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); A61K 38/177 (2013.01); A61K 2039/505 (2013.01); C07K 14/705 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01);
Abstract

The present invention provides a fusion protein inhibiting TACI-BAFF complex formation and preparation method therefor and use thereof. Specifically, the fusion protein of the present invention is of high biological activity for blocking BAFF/APPRIL, and may significantly lower the serum IgM concentration in normal Balb/c mice as well as the serum IgM and IgE concentration in C57/B6 mice with asthma. The TACI-Fc fusion protein of the present invention may be used in the treatment of autoimmune diseases, including asthma, systemic lupus eythematosus and rheumatoid arthritis, etc., and may also be used in the treatment of B cell enrichment-related diseases, including multiple myeloma, chronic lymphocytic leukemia, macroglobulinemia and plasmacytic leukemia, etc.

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