The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Dec. 29, 2016
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, CN;
Xiquan Zhang, Lianyungang, CN;
Aiming Zhang, Lianyungang, CN;
Zhou Zhou, Lianyungang, CN;
Leilei Yang, Lianyungang, CN;
Huadong Yao, Lianyungang, CN;
Xueyan Zhu, Lianyungang, CN;
Hubo Wang, Lianyungang, CN;
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, CN;
Abstract
The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.