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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10562878 B1

PDFFull Text
Date of Patent:
Feb. 18, 2020

Filed:

Dec. 08, 2017

Cycloalkylamines as monoamine reuptake inhibitors

Applicant:

Sunovion Pharmaceuticals Inc., Marlborough, MA (US);

Inventors:

Liming Shao, Lincoln, MA (US);

Fengjiang Wang, Northborough, MA (US);

Scott Christopher Malcolm, Southborough, MA (US);

Michael Charles Hewitt, Somerville, MA (US);

Larry R. Bush, Worcester, MA (US);

Jianguo Ma, Natick, MA (US);

Mark A. Varney, Laguna Nigel, CA (US);

Una Campbell, Marlborough, MA (US);

Sharon Rae Engel, Hudson, MA (US);

Larry Wendell Hardy, Sturbridge, MA (US);

Patrick Koch, Marlborough, MA (US);

John E. Campell, Waban, MA (US);

Assignee:

SUNOVION PHARAMCEUTICALS INC., Marlborough, MA (US);

Attorney:
Primary Examiner:

David K O'Dell

Int. Cl.
CPC ...
C07D 333/20 (2006.01); C07C 211/17 (2006.01); C07C 211/40 (2006.01); C07C 215/42 (2006.01); C07C 215/44 (2006.01); C07C 217/52 (2006.01); C07C 217/74 (2006.01); C07C 323/32 (2006.01); C07D 207/06 (2006.01); C07D 207/08 (2006.01); C07D 211/14 (2006.01); C07D 265/14 (2006.01); C07D 277/28 (2006.01); C07D 295/06 (2006.01); C07D 307/52 (2006.01); C07D 317/58 (2006.01); C07D 317/72 (2006.01); C07D 319/06 (2006.01); C07D 491/056 (2006.01); C07C 211/29 (2006.01); C07D 211/16 (2006.01);
U.S. Cl.
CPC ...
C07D 333/20 (2013.01); C07C 211/17 (2013.01); C07C 211/29 (2013.01); C07C 211/40 (2013.01); C07C 215/42 (2013.01); C07C 215/44 (2013.01); C07C 217/52 (2013.01); C07C 217/74 (2013.01); C07C 323/32 (2013.01); C07D 207/06 (2013.01); C07D 207/08 (2013.01); C07D 211/14 (2013.01); C07D 211/16 (2013.01); C07D 265/14 (2013.01); C07D 277/28 (2013.01); C07D 295/06 (2013.01); C07D 307/52 (2013.01); C07D 317/58 (2013.01); C07D 317/72 (2013.01); C07D 319/06 (2013.01); C07D 491/056 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05); C07C 2601/10 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2602/08 (2017.05);
Abstract

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

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