The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 18, 2020

Filed:

Nov. 14, 2016
Applicant:

Afasci, Inc., Redwood City, CA (US);

Inventors:

Xinmin Xie, Burlingame, CA (US);

Frank Kayser, San Francisco, CA (US);

Assignee:

AFASCI, INC., Burlingame, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/20 (2006.01); A61K 31/4747 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01); C07D 413/14 (2006.01); C07D 211/26 (2006.01); C07D 413/12 (2006.01); C07D 211/58 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C07D 221/20 (2013.01); C07D 211/26 (2013.01); C07D 211/58 (2013.01); C07D 401/12 (2013.01); C07D 405/06 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01);
Abstract

The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and/or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.


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