The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Dec. 23, 2018
Applicant:
The Feinstein Institutes for Medical Research, Manhasset, NY (US);
Inventors:
Kevin J. Tracey, Old Greenwich, CT (US);
Jared M. Huston, New York, NY (US);
Assignee:
The Feinstein Institutes for Medical Research, Manhasset, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 1/36 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
A61N 1/36167 (2013.01); A61K 31/44 (2013.01); A61N 1/3606 (2013.01); A61N 1/36053 (2013.01); Y02A 50/385 (2018.01); Y02A 50/411 (2018.01);
Abstract
A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.