The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Dec. 21, 2018
Codiak Biosciences, Inc., Cambridge, MA (US);
Kevin P. Dooley, Boston, MA (US);
Rane A. Harrison, Belmont, MA (US);
Russell E. McConnell, Brighton, MA (US);
Ke Xu, Sudbury, MA (US);
Damian J. Houde, Plymouth, MA (US);
Nikki Ross, Cambridge, MA (US);
Sonya Haupt, Cambridge, MA (US);
John D. Kulman, Belmont, MA (US);
Douglas E. Williams, Boston, MA (US);
Other;
Abstract
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.