The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
May. 09, 2016
Applicant:
Arbutus Biopharma Corporation, Burnaby, CA;
Inventors:
Assignee:
ARBUTUS BIOPHARMA CORPORATION, Burnaby, BC, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/18 (2017.01); A61K 9/14 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); C12N 15/113 (2010.01); C07C 271/20 (2006.01); C07C 217/08 (2006.01); C07C 229/12 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
A61K 47/18 (2013.01); A61K 9/145 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 38/00 (2013.01); C07C 217/08 (2013.01); C07C 229/12 (2013.01); C07C 271/20 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.