The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 11, 2020

Filed:

Apr. 04, 2016
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Craig A. Stump, Pottstown, PA (US);

Yi Heng Chen, Whippany, NJ (US);

Ping Liu, Westfield, NJ (US);

Dongfang Meng, Morganville, NJ (US);

Jane Yang Wu, Marlboro, NJ (US);

Chun Sing Li, Shanghai, CN;

Zhiqi Qi, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); A61P 7/02 (2006.01); A61P 17/06 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 7/02 (2018.01); A61P 9/10 (2018.01); A61P 17/06 (2018.01); A61P 25/00 (2018.01); A61P 35/00 (2018.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.


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