The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2020
Filed:
Oct. 23, 2015
Applicant:
Shire Human Genetic Therapies, Inc., Lexington, MA (US);
Inventors:
Bohong Zhang, Lexington, MA (US);
Michael F. Concino, Lexington, MA (US);
Assignee:
Criteo S.A., Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/65 (2017.01); C12N 9/64 (2006.01); C12N 9/24 (2006.01); A61K 47/64 (2017.01); C12N 9/96 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
A61K 47/65 (2017.08); A61K 47/64 (2017.08); C12N 9/2402 (2013.01); C12N 9/6454 (2013.01); C12N 9/96 (2013.01); C12N 15/62 (2013.01); C12Y 302/0102 (2013.01); C12Y 302/0105 (2013.01); C07K 2319/06 (2013.01); C07K 2319/50 (2013.01);
Abstract
The invention provides compositions and methods for effective lysosomal targeting mediated by PCSK9. In particular, the compositions and methods provided by the invention may be used to treat lysosomal storage diseases such as Pompe Disease and Sanfilippo Syndrome Type B, and they may be used for targeting lysosomal enzymes to the various muscles of the human body.