The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 11, 2020
Filed:
Feb. 24, 2017
Applicant:
Innopeutics Corporation, Seoul, KR;
Inventors:
Sang-Hun Lee, Seoul, KR;
Sang-Min Oh, Seoul, KR;
Assignee:
INNOPEUTICS CORPORATION, Seoul, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/18 (2006.01); C07K 14/475 (2006.01); A61K 35/30 (2015.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 5/079 (2010.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/30 (2013.01); A61K 38/1709 (2013.01); A61K 38/1783 (2013.01); C07K 14/4705 (2013.01); C07K 14/70567 (2013.01); C12N 5/0622 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2502/081 (2013.01); C12N 2502/086 (2013.01); C12N 2510/00 (2013.01); C12N 2740/16043 (2013.01);
Abstract
A therapeutic effect of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells is provided. Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided.