The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Mar. 04, 2016
Applicant:
Tagcyx Biotechnologies, Meguro-ku, Tokyo, JP;
Inventors:
Assignee:
Tagcyx Biotechnologies, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C12N 2310/16 (2013.01); C12N 2310/33 (2013.01); C12N 2310/334 (2013.01); C12N 2310/336 (2013.01); C12N 2310/51 (2013.01); C12N 2310/531 (2013.01); C12N 2320/51 (2013.01); C12N 2320/52 (2013.01);
Abstract
An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and a DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.