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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10550386 B1

PDFFull Text
Date of Patent:
Feb. 04, 2020

Filed:

Dec. 30, 2016

Monomers and oligonucleotides comprising cycloaddition adduct(s)

Applicant:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Muthiah Manoharan, Cambridge, MA (US);

Jayaprakash K. Nair, Cambridge, MA (US);

Kallanthottahil G. Rajeev, Cambridge, MA (US);

Michael E. Jung, Cambridge, MA (US);

Assignee:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:

Jeffrey N. Townes

Cozen O'Connor

Primary Examiner:

Eric Olson

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 403/14 (2006.01); C12N 15/113 (2010.01); C07F 9/572 (2006.01); C07D 249/16 (2006.01); C07D 487/04 (2006.01); C07D 493/04 (2006.01); C07D 493/08 (2006.01); C07D 495/04 (2006.01); C07D 495/08 (2006.01); C07F 9/655 (2006.01); C07F 9/6558 (2006.01); C07H 19/067 (2006.01); A61K 31/7088 (2006.01); A61K 31/711 (2006.01); A61K 31/713 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/7088 (2013.01); A61K 31/711 (2013.01); A61K 31/713 (2013.01); C07D 249/16 (2013.01); C07D 403/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 493/04 (2013.01); C07D 493/08 (2013.01); C07D 495/04 (2013.01); C07D 495/08 (2013.01); C07F 9/572 (2013.01); C07F 9/65515 (2013.01); C07F 9/65586 (2013.01); C07H 19/067 (2013.01); C12N 2310/14 (2013.01); C12N 2310/351 (2013.01);
Abstract

The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

Find Patent Forward Citations

Manoharan, Muthiah. (2020). Monomers and oligonucleotides comprising cycloaddition adduct(s) (U.S. Patent No. 10550386). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10550386

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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