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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10550176 B1

PDFFull Text
Date of Patent:
Feb. 04, 2020

Filed:

Dec. 04, 2015

Viral vectors encoding multiple highly homologous non-viral polypeptides and the use of same

Applicant:

Roger Williams Hospital, Providence, RI (US);

Inventors:

Wen Yang, Sharon, MA (US);

Richard P. Junghans, Boston, MA (US);

Anthony J. Bais, Providence, RI (US);

Assignee:

ROGER WILLIAMS MEDICAL CENTER, Providence, RI (US);

Attorney:

McDermott Will & Emery LLP

Primary Examiner:

Christopher M Babic

Assistant Examiner:

Kimberly A Aron

Int. Cl.
CPC ...
C07K 16/18 (2006.01); C12N 15/86 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 16/08 (2006.01); C07K 16/40 (2006.01); C12N 7/00 (2006.01); A61K 35/00 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/084 (2013.01); C07K 16/40 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 35/00 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/70 (2013.01); C12N 2740/10032 (2013.01); C12N 2740/10052 (2013.01); C12N 2740/13043 (2013.01); C12N 2740/13045 (2013.01); C12N 2810/855 (2013.01); C12N 2810/859 (2013.01);
Abstract

The present invention relates to compositions and methods for creation of vector nucleic acid sequences (e.g., retroviral nucleic acid sequences) that comprise two or more exogenous nucleic acid sequences that encode highly homologous (e.g., identical) polypeptide sequences, yet wherein at least one of the exogenous nucleic acid sequences has been mutated using degenerate codons for purpose of reducing homology between the two or more exogenous nucleic acid sequences while maintaining the encoded polypeptide sequence. Preferred nucleic acid sequences include those encoding multi-chimeric immune receptor (CIR) genes. Specific nucleic acid sequences of such CIR genes are also disclosed.

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Yang, Wen. (2020). Viral vectors encoding multiple highly homologous non-viral polypeptides and the use of same (U.S. Patent No. 10550176). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10550176

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