The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Apr. 18, 2017
Applicant:
Intercept Pharmaceuticals, Inc., New York, NY (US);
Inventors:
Benjamin List, Muelheim an de Ruhr, DE;
Chandra Kanta De, Muelheim an der Ruhr, DE;
Qinggang Wang, Qingdao, CN;
Assignee:
Intercept Pharmaceuticals, Inc., New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07J 9/00 (2006.01); C07J 31/00 (2006.01);
U.S. Cl.
CPC ...
C07J 9/005 (2013.01); C07J 9/00 (2013.01); C07J 31/006 (2013.01);
Abstract
The present application relates to a safe method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, on a large scale from 7-keto lithocholic acid (KLCA), comprising reacting Compound 2 with paraldehyde to form Compound 3 at a temperature between 10° C. and 30° C.: