The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 04, 2020

Filed:

May. 11, 2017
Applicant:

Heptares Therapeutics Limited, Cambridge, GB;

Inventors:

John Graham Cumming, Basel, CH;

Frank Xinhe Wu, Waltham, MA (US);

Karl Henrik Edman, Mölndal, SE;

Hongming Chen, Mölndal, SE;

Dean Gordon Brown, Waltham, MA (US);

Roland Werner Burli, Cambridge, GB;

Shawn Donald Johnstone, Saint Laurent, CA;

Giles Albert Brown, Cambridge, GB;

Benjamin Gerald Tehan, Cambridge, GB;

Barry John Teobald, Cambridge, GB;

Miles Stuart Congreve, Cambridge, GB;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/64 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 405/06 (2006.01); C07D 409/06 (2006.01); C07D 413/10 (2006.01); C07D 417/10 (2006.01); C07D 249/08 (2006.01); C07D 471/04 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61K 31/4164 (2006.01);
U.S. Cl.
CPC ...
C07D 233/64 (2013.01); A61P 17/00 (2018.01); A61P 29/00 (2018.01); C07D 249/08 (2013.01); C07D 403/06 (2013.01); C07D 403/10 (2013.01); C07D 405/06 (2013.01); C07D 409/06 (2013.01); C07D 413/10 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); A61K 31/4164 (2013.01);
Abstract

The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R-Rare as defined herein.


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