The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Mar. 21, 2019
Institute of Applied Biochemistry, Kani-gun, Gifu Prefecture, JP;
Satoru Sugiyama, Kani-gun, JP;
Katsuhiro Hayashi, Kani-gun, JP;
INSTITUTE OF APPLIED BIOCHEMISTRY, Kani-Gun, Gifu Prefecture, JP;
Abstract
To provide a compound and a tumor therapeutic agent which are highly effective in cancer therapy and are less likely to cause hypertension as a side effect, and to provide development of a drug for elucidating the action mechanism of lenvatinib to help further development of new drugs. The lenvatinib derivative of the present invention comprises a compound represented by the following chemical structural formula (1) (wherein R represents an alkylene group which may have a branch) and a salt thereof, and a solvate thereof. This derivative has a nitric acid ester group, and thus produces nitric oxide (NO) having a vasodilating action in vivo, so that a higher-concentration lenvatinib component can be expected to arrive at target molecules present in cancer cells and vascular endothelial cells on the host side and also can suppress hypertension as a side effect.