The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
May. 19, 2016
Applicants:
Celgene Corporation, Summti, NJ (US);
Maria Cappellini, Milan, IT;
Inventors:
Maria Cappellini, Milan, IT;
Victoria Sung, San Francisco, CA (US);
Assignee:
Celgene Corporation, Summit, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61P 7/00 (2006.01); C12Q 1/02 (2006.01); G01N 33/483 (2006.01); A61K 35/18 (2015.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 35/18 (2013.01); A61K 38/179 (2013.01); A61K 39/39541 (2013.01); A61P 7/00 (2018.01); C12Q 1/025 (2013.01); G01N 33/4833 (2013.01); A61K 2039/505 (2013.01); A61K 2039/515 (2013.01);
Abstract
Provided herein are methods of treating beta-thalassemia in a subject comprising administering to the subject an activin type II receptor (ActRII) signaling inhibitor (e.g., an activin ligand trap) and utilizing one or more in vitro cell culture methods provided herein in (i) selection of the subject to be treated according to the methods provided herein; and/or (ii) monitoring of the subject being treated according to the methods provided herein.