The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Sep. 23, 2016
Massachusetts Institute of Technology, Cambridge, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Omar F. Khan, Cambridge, MA (US);
Jasdave S. Chahal, Arlington, MA (US);
Daniel G. Anderson, Framington, MA (US);
Hidde Ploegh, Brookline, MA (US);
Robert S. Langer, Newton, MA (US);
Tyler E. Jacks, Newton, MA (US);
David A. Canner, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambirdge, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Abstract
Compositions and methods for modified dendrimer nanoparticle ('MDNP') delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.