The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Sep. 26, 2013
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Harvey Cantor, Boston, MA (US);
Hye-Jung Kim, Brookline, MA (US);
Jianmei Wu Leavenworth, Hoover, AL (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 35/17 (2015.01); C07K 14/47 (2006.01); C07K 14/74 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 39/0008 (2013.01); A61K 35/17 (2013.01); C07K 14/47 (2013.01); C07K 14/70539 (2013.01); C12N 5/0636 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/58 (2013.01); C12N 2501/2315 (2013.01);
Abstract
Nanoparticles to treat autoimmune diseases and HIV infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (MHC) class I antigen E (HLA-E) linked to a peptide, and wherein the HLA-E-peptide complex is linked to the surface of the nanoparticle. The present invention also relates to methods for treating autoimmune diseases and HIV infection.