The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2020
Filed:
Aug. 14, 2014
Bioverativ Therapeutics Inc., Waltham, MA (US);
Tongyao Liu, Lexington, MA (US);
Pei-Yun Chang, Menlo Park, CA (US);
John Kulman, Belmont, MA (US);
Volker Schellenberger, Palo Alto, CA (US);
Haiyan Jiang, Belmont, MI (US);
Robert T. Peters, Needham, MA (US);
Ekta Seth Chhabra, Framingham, MA (US);
BIOVERATIV THERAPEUTICS INC., Waltham, MA (US);
Abstract
The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.