The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Jun. 24, 2015
Applicant:
Pharmazell Gmbh, Raubling, DE;
Inventors:
Assignee:
PharmaZell GmbH, Raubling, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 33/00 (2006.01); C12N 9/04 (2006.01);
U.S. Cl.
CPC ...
C12P 33/00 (2013.01); C12N 9/0006 (2013.01); C12Y 101/01047 (2013.01); C12Y 101/01145 (2013.01); C12Y 101/01201 (2013.01);
Abstract
The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7β-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for producing the enzyme mutants and use thereof in enzymatic conversions of cholic acid compounds, and in particular in the production of ursodesoxycholic acid (UDCA); also a subject of the invention are novel methods for the synthesis of UDCA using the enzyme mutants; and in particular a further improved method for producing UDCA using recombinant whole cell biocatalysts.