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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10544420 B1

PDFFull Text
Date of Patent:
Jan. 28, 2020

Filed:

Oct. 01, 2018

Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids

Applicant:

Antheia, Inc., Menlo Park, CA (US);

Inventors:

Christina D. Smolke, Menlo Park, CA (US);

Derek H. Wells, Palo Alto, CA (US);

Assignee:

Antheia, Inc., Menlo Park, CA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Ganapathirama Raghu

Int. Cl.
CPC ...
C12N 15/22 (2006.01); C12N 9/06 (2006.01); C12P 17/18 (2006.01); C12P 17/12 (2006.01); C12N 15/62 (2006.01); C12N 9/02 (2006.01); C12N 9/90 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12N 15/52 (2013.01); C12N 9/0014 (2013.01); C12N 9/0026 (2013.01); C12N 9/0071 (2013.01); C12N 9/90 (2013.01); C12P 17/12 (2013.01); C12P 17/18 (2013.01); C12Y 105/01027 (2013.01); C12Y 114/19 (2013.01); C12Y 501/01 (2013.01);
Abstract

The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in an engineered host cell. A (S)-1-benzylisoquinoline alkaloid is contacted with said engineered epimerase. Contacting said (S)-1-benzylisoquinoline alkaloid with said engineered epimerase converts said (S)-1-benzylisoquinoline alkaloid to said (R)-1-benzylisoquinoline alkaloid.

Find Patent Forward Citations

Smolke, Christina. (2020). Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids (U.S. Patent No. 10544420). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10544420

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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