The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Aug. 27, 2014
Applicants:
Stan Gronthos, Adelaide, AU;
Andrew Christopher William Zannettino, Highbury, AU;
Inventors:
Stan Gronthos, Adelaide, AU;
Andrew Christopher William Zannettino, Highbury, AU;
Assignee:
Mesoblast, Inc., New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 5/00 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0652 (2013.01); C12N 2501/125 (2013.01); C12N 2501/135 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2301 (2013.01); C12N 2501/2303 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/25 (2013.01); C12N 2501/999 (2013.01); C12N 2502/13 (2013.01);
Abstract
The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.