The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Nov. 17, 2016
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Juha Punnonen, Belmont, CA (US);
Edward Bowman, Redwood City, CA (US);
Maribel Beaumont, San Mateo, CA (US);
Marie-Ange Buyse, Merelbeke, BE;
Carlo Boutton, Wielsbeke, BE;
Bruno Dombrecht, Heusden, BE;
Bjorn Victor, Zwijndrecht, BE;
David Vlerick, Gentbrugge, BE;
Robert A. Kastelein, Portola Valley, CA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.