The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Jul. 09, 2018
Applicant:
Morehouse School of Medicine, Atlanta, GA (US);
Inventors:
Vincent Craig Bond, Stone Mountain, GA (US);
James W. Lillard, Jr., Smyrna, GA (US);
Ming Bo Huang, Atlanta, GA (US);
Assignee:
MOREHOUSE SCHOOL OF MEDICINE, Atlanta, GA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); A61K 38/16 (2006.01); A61K 47/64 (2017.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 19/00 (2006.01); C07K 14/005 (2006.01); A61K 45/06 (2006.01); C12N 7/00 (2006.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 38/10 (2013.01); A61K 38/16 (2013.01); A61K 38/162 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 47/641 (2017.08); C07K 7/08 (2013.01); C07K 14/00 (2013.01); C12N 7/00 (2013.01); C07K 2319/035 (2013.01); C07K 2319/70 (2013.01); C07K 2319/74 (2013.01); C12N 2740/16022 (2013.01); C12N 2740/16322 (2013.01);
Abstract
A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.