The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 28, 2020

Filed:

Feb. 16, 2016
Applicant:

Suzhou Zelgen Biopharmaceuticals Co., Ltd., Kunshan Suzhou, Jiangsu, CN;

Inventors:

Binhua Lv, Jiangsu, CN;

Zelin Sheng, Jiangsu, CN;

Chengwei Li, Jiangsu, CN;

Assignee:

Suzhou Zelgen Biopharmaceuticals Co., Ltd., Kunshan, Suzhou, Jiangsu, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 9/00 (2006.01); A61K 31/575 (2006.01); A61K 45/06 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07J 9/005 (2013.01); A61K 31/575 (2013.01); A61K 45/06 (2013.01); C07B 59/007 (2013.01); C07B 2200/05 (2013.01);
Abstract

Disclosed are deuterated chenodeoxycholic acid derivatives and pharmaceutical compositions containing the deuterated chenodeoxycholic acid derivatives. In particular, disclosed is a deuterated chenodeoxycholic acid derivative of formula (I), or a crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof, and a pharmaceutical composition containing the same. The deuterated chenodeoxycholic acid derivatives of formula (I) can be used to treat and/or prevent diseases related to the farnesoid X receptor (FXR) and/or G-protein coupled bile acid receptor, such as nonalcoholic steatohepatitis, nonalcoholic fatty liver diseases, gallstones, primary biliary cirrhosis, and cirrhosis.


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