The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Aug. 04, 2014
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Fuxin, CN;
Jilin Asymchem Laboratories Co., Ltd., Dunhua, CN;
Hao Hong, Tianjin, CN;
Chaoyong Chen, Tianjin, CN;
Jiuyuan Li, Tianjin, CN;
Litao Shen, Tianjin, CN;
Lina Guo, Tianjin, CN;
Hongying Tian, Tianjin, CN;
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co. Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Liaoning, CN;
Jilin Asymchem Laboratories Co., Ltd., Jilin, CN;
Abstract
The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield.