The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2020
Filed:
Jul. 10, 2013
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Emory University, Atlanta, GA (US);
Children's Healthcare of Atlanta, Atlanta, GA (US);
Binghe Wang, Marietta, GA (US);
Chaofeng Dai, Atlanta, GA (US);
Alexander Draganov, Atlanta, GA (US);
Xiaochuan Yang, Baltimore, MD (US);
Guojing Sun, Atlanta, GA (US);
Chunhao Yang, Shanghai, CN;
Weixuan Chen, Atlanta, GA (US);
Nanting Ni, Goleta, CA (US);
Muxiang Zhou, Tucker, GA (US);
Lubing Gu, Tucker, GA (US);
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Emory University, Atlanta, GA (US);
Children's Healthcare of Atlanta, Inc., Atlanta, GA (US);
Abstract
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.