The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 28, 2020

Filed:

Apr. 11, 2016
Applicant:

Rutgers, the State University of New Jersey, New Brunswick, NJ (US);

Inventors:

Kathryn Uhrich, New Brunswick, NJ (US);

Kervin Smith, New Brunswick, NJ (US);

Jonathan Faig, New Brunswick, NJ (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 8/85 (2006.01); A61K 31/351 (2006.01); A61K 47/59 (2017.01); A61K 8/49 (2006.01); A61K 9/00 (2006.01); A61P 17/00 (2006.01); A61Q 19/02 (2006.01); C08G 64/06 (2006.01);
U.S. Cl.
CPC ...
A61K 8/85 (2013.01); A61K 8/498 (2013.01); A61K 9/0014 (2013.01); A61K 31/351 (2013.01); A61K 47/593 (2017.08); A61P 17/00 (2018.01); A61Q 19/02 (2013.01); C08G 64/06 (2013.01);
Abstract

A controlled release system for kojic acid having improved stability has been identified. To minimize degradation, kojic acid was incorporated into a hydrolytically degradable polymer (e.g., a polycarbonate-ester)). By synthesizing polymer precursors containing kojic acid-linker-kojic acid chemical structures, versatile monomers were developed that can be used to modulate polymer properties. Additionally the synthetic method lends itself to the development of other polymer systems. Polymers having one or more groups that will yield kojic acid upon degradation of the polymer backbone, as well as methods of use thereof are described.


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