The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 21, 2020

Filed:

Aug. 06, 2013
Applicants:

Fujirebio Inc., Tokyo, JP;

Sekisui Medical Co., Ltd., Tokyo, JP;

Inventors:

Kentaro Yamaguchi, Tokyo, JP;

Katsumi Aoyagi, Tokyo, JP;

Azusa Terao, Tokyo, JP;

Assignees:

FUJIREBIO INC., Tokyo, JP;

SEKISUI MEDICAL CO., LTD., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 33/86 (2006.01); C07K 14/745 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54306 (2013.01); C07K 14/745 (2013.01); G01N 33/57438 (2013.01); G01N 33/86 (2013.01); G01N 2333/745 (2013.01);
Abstract

Disclosed are a PIVKA-II measurement method that achieves better serum-plasma correlation than conventional methods, and a reagent and a kit therefor. The PIVKA-II measurement method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using a mixture of an anti-F1 antibody that specifically binds to prothrombin fragment F1 or an antigen-binding fragment thereof and an anti-F2 antibody that specifically binds to prothrombin fragment F2 or an antigen-binding fragment thereof; and an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof.


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