The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 21, 2020

Filed:

Feb. 06, 2015
Applicants:

Omrix Biopharmaceuticals Ltd., Rehovot, IL;

Guangzhou Bioseal Biotech Co., Ltd., Guangzhou, CN;

Inventors:

Lior Weissman, Ness-Ziona, IL;

Dana Sella, Rehovot, IL;

Israel Nur, Nes-Ziona, IL;

Caixia Jiang, Guangzhou, CN;

Baochang An, Guangzhou, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); G01N 33/84 (2006.01); G01N 33/86 (2006.01); C12N 9/74 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6429 (2013.01); C12Y 304/21005 (2013.01); G01N 33/84 (2013.01); G01N 33/86 (2013.01); G01N 2333/745 (2013.01);
Abstract

The present invention is directed to methods for the production of thrombin from a source of prothrombin using a given BaSOreagent as an adsorbent of prothrombin as well as methods for evaluating the suitability of a given BaSOreagent for use in preparation of thrombin. In at least one embodiment, the method includes contacting a sample of the given BaSOreagent with a source of prothrombin to obtain BaSO-adsorbed prothrombin, and subsequently evaluating the pro-coagulant activity of the BaSO-adsorbed prothrombin. In another embodiment, the method includes the step of evaluating relative to the pro-coagulant activity of normal mammalian plasma.


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