The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2020
Filed:
Jan. 19, 2018
Applicant:
U.s. Army Edgewood Chemical Biological Center, APG, MD (US);
Inventors:
Steven P Harvey, Lutherville, MD (US);
Melissa M Dixon, Abingdon, MD (US);
Mark A Guelta, White Marsh, MD (US);
Assignee:
The United States of America as Represented by the Secretary of the Army, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 38/46 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); C12Y 301/08002 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having two site mutations, methods of production, and methods of use to effectively degrade cylcosarin (GF) (cyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA.