The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2020
Filed:
May. 16, 2018
Memorial Sloan-kettering Cancer Center, New York, NY (US);
The U.s.a. As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Prasad S. Adusumilli, New York, NY (US);
Michel Sadelain, New York, NY (US);
Dimiter S. Dimitrov, Frederick, MD (US);
Yang Feng, Frederick, MD (US);
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US);
Abstract
The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.