The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2020
Filed:
Apr. 05, 2019
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Jeffrey Charles Way, Cambridge, MA (US);
Avram Lev Robinson-Mosher, Cambridge, MA (US);
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/56 (2006.01); C07K 16/28 (2006.01); A61K 38/21 (2006.01); A61K 39/395 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/56 (2013.01); A61K 38/212 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01);
Abstract
Aspects of the disclosure provide fusion proteins that bind cells expressing one or more target molecules including, for example, one or more cell surface multisubunit signaling receptors (e.g., EGFRvIII-expressing cells that also express interferon receptors) and that induce anti-proliferative effects, and related compositions and methods for the treatment of cancer.