IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10538497 B1

PDFFull Text
Date of Patent:
Jan. 21, 2020

Filed:

Dec. 12, 2016

Compounds as indoleamine 2,3-dioxygenase inhibitors

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Yongxin Han, Needham, MA (US);

Abdelghani Achab, Melrose, MA (US);

Purakkattle Biju, Westwood, MA (US);

Yongqi Deng, Newton, MA (US);

Xavier Fradera, Brookline, MA (US);

Liangqin Guo, Monroe, NJ (US);

Shuwen He, Fanwood, NJ (US);

Joseph Kozlowski, Princeton, NJ (US);

Ravi Kurukulasuriya, Niantic, CT (US);

Kun Liu, Needham, MA (US);

Meredeth Ann McGowan, Boston, MA (US);

Qinglin Pu, Needham, MA (US);

Nunzio Sciammetta, Sudbury, MA (US);

Hongjun Zhang, Boston, MA (US);

Hua Zhou, Acton, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Yong Zhao

Anna L. Cocuzzo

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
A61K 31/4245 (2006.01); A61K 31/433 (2006.01); C07D 271/08 (2006.01); C07D 285/10 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); A61P 35/00 (2006.01); A61P 31/12 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 37/06 (2006.01); A61P 27/12 (2006.01); A61P 31/14 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
C07D 271/08 (2013.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01); A61P 27/12 (2018.01); A61P 31/14 (2018.01); A61P 35/02 (2018.01); A61P 37/06 (2018.01); C07D 285/10 (2013.01); C07D 413/12 (2013.01);
Abstract

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

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