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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10538491 B1

PDFFull Text
Date of Patent:
Jan. 21, 2020

Filed:

Mar. 16, 2016

4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators

Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

P. Jeffrey Conn, Nashville, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Kyle A. Emmitte, Aledo, TX (US);

Andrew S. Felts, Brentwood, TN (US);

Katrina A. Bollinger, Murfreesboro, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorney:

Michael Best & Friedrich LLP

Primary Examiner:

Valerie Rodriguez-Garcia

Int. Cl.
CPC ...
C07D 213/81 (2006.01); C07D 401/14 (2006.01); C07D 213/84 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); A61K 31/02 (2006.01); A61K 31/165 (2006.01); A61K 31/277 (2006.01);
U.S. Cl.
CPC ...
C07D 213/81 (2013.01); C07D 213/84 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); A61K 31/02 (2013.01); A61K 31/165 (2013.01); A61K 31/277 (2013.01);
Abstract

4,5-Substituted Picolinamide and picolinonitrile compounds of formula (I), where Ris CONHor CN and Ris an optionally substituted aryl or heteroaryl, are negative allosteric modulators of the metabotropic glutamate receptor 2 (mGlu). The compounds and pharmaceutical compositions including the compounds may be useful for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer's disease, or autism spectrum disorders in a subject.

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