The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2020
Filed:
Aug. 15, 2016
Applicant:
Rc Biotechnologies, Inc., Fremont, CA (US);
Inventors:
Chang Jiang Huang, Los Angeles, CA (US);
Jianmin Fang, Palo Alto, CA (US);
Hui Ye, Shandong, CN;
Lezhi Zhang, Shandong, CN;
Assignee:
RC BIOTECHNOLOGIES, INC., Fremont, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61K 31/44 (2006.01); C07D 257/08 (2006.01); A61K 47/54 (2017.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/545 (2017.08); A61K 47/54 (2017.08); A61K 47/6803 (2017.08); A61K 47/6811 (2017.08); A61K 47/6855 (2017.08); A61K 47/6869 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 16/2896 (2013.01); C07K 16/32 (2013.01);
Abstract
The present invention provides novel and advantageous compositions having a linker capable of covalently coupling one or more free thiols of an antibody. Specifically, provided herein are the molecular structures, synthetic pathways, coupling mechanisms, and applications thereof as used in an antibody-drug conjugate (ADC).