The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 21, 2020
Filed:
Oct. 22, 2016
Microbiology Institute of Shaanxi, Xi'an, CN;
Institute of Biophysics, Chinese Academy of Sciences, Beijing, CN;
Yi Wan, Xi'an, CN;
Chang Chen, Beijing, CN;
Lei Gao, Xi'an, CN;
Yuying Zhang, Beijing, CN;
Xinhua Qiao, Beijing, CN;
Yan Wang, Xi'an, CN;
Other;
Abstract
Provided are a method, target and application for NO accumulation to decrease invasiveness of; achieving NO accumulation by means of external NO donors or disruption of internal NO metabolism in an environment whereis growing or being cultured, in order to decrease production byof the invasion factor pyocyanin. Utilizing even micro-quantities of NO can significantly inhibitPCN (PCN synthesis down 82% with 60 μM SNP treatment); by inhibiting NO reductase, an enzyme related to NO metabolism, PCN synthesis can be significantly inhibited (the PAO1-Δnor strain has 84% PCN reduction). Using NO donors or inhibiting enzymes involved inNO metabolism as a means of combating bacterial infectious disease does not affect the body's normal microflora like traditional antibiotics.