The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2020
Filed:
Jul. 07, 2017
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);
J. Marc Simard, Baltimore, MD (US);
Mingkui Chen, Lake Forest, IL (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America as Represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
A composition comprising a novel Ca-activated, [ATP]-sensitive nonspecific cation (NC) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]. The NCchannel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCchannel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCchannel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.