The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 14, 2020

Filed:

Nov. 10, 2017
Applicant:

Quantum-si Incorporated, Guilford, CT (US);

Inventors:

Jonathan M. Rothberg, Guilford, CT (US);

Ali Kabiri, Madison, CT (US);

Jason W. Sickler, Madison, CT (US);

Brett J. Gyarfas, Guilford, CT (US);

Jeremy Lackey, Guilford, CT (US);

Gerard Schmid, Guilford, CT (US);

Benjamin Cipriany, Branford, CT (US);

Jack Jewell, Boulder, CO (US);

Lawrence C. West, San Jose, CA (US);

Michael Ferrigno, Farmington, CT (US);

Paul E. Glenn, Wellesley, MA (US);

Adam Ezra Cohen, Cambridge, MA (US);

Anthony Bellofiore, Glastonbury, CT (US);

Assignee:

Quantum-Si Incorporated, Guilford, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); C12Q 1/6874 (2018.01); G01N 21/77 (2006.01); C12Q 1/6869 (2018.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6486 (2013.01); B01L 3/5085 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6874 (2013.01); G01N 21/64 (2013.01); G01N 21/645 (2013.01); G01N 21/648 (2013.01); G01N 21/6452 (2013.01); G01N 21/7743 (2013.01); G01N 21/7746 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/0893 (2013.01); B01L 2300/168 (2013.01); C12Q 2521/101 (2013.01); C12Q 2525/101 (2013.01); C12Q 2537/157 (2013.01); C12Q 2563/107 (2013.01); C12Q 2565/607 (2013.01); G01N 2021/6419 (2013.01); G01N 2021/6441 (2013.01); G01N 2021/6478 (2013.01); G01N 2201/02 (2013.01); G01N 2201/062 (2013.01); G01N 2201/068 (2013.01); G01N 2201/0612 (2013.01); G01N 2201/06113 (2013.01); G01N 2201/125 (2013.01); Y10T 29/49016 (2015.01);
Abstract

Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.


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