The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2020
Filed:
Mar. 25, 2015
Simatech Incorporation, Suzhou, Jiangsu, CN;
Xiaoqin Wang, Jiangsu, CN;
Jian Liu, Jiangsu, CN;
Jianbing Wu, Jiangsu, CN;
Cheng Qian, Jiangsu, CN;
Zhaozhu Zheng, Jiangsu, CN;
Shaozhe Guo, Jiangsu, CN;
Fuxin Shi, Jiangsu, CN;
David Kaplan, Medford, MA (US);
SIMATECH INCORPORATION, Suzhou, CN;
TRUSTEES OF TUFTS COLLEGE, Medford, MA (US);
Abstract
The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution, dialysis, centrifugation, high temperature and high pressure treatment and freeze-drying. A method of preparing silk fibroin microspheres with polyethylene glycol comprises mixing a silk fibroin solution of 1-30 wt % with a PEG solution of 10-60 w % and incubating the resulting solution. A controlled-release or sustained-release silk fibroin gel formulation includes a gel-state carrier and a drug dispersed/adsorbed therein, the carrier is a silk fibroin gel formed by blending with LMW-PEG. The freeze-dried powder will not change the native molecular weight and random coil structure of silk fibroin, and can be rapidly dissolved into a solution, and can be stored and transported for a long time, and this reduces waste of silk fibroin materials and promotes R & D and biomedical applications of silk fibroin biomaterials.