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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10533006 B1

PDFFull Text
Date of Patent:
Jan. 14, 2020

Filed:

Feb. 03, 2017

Nitrogen-containing heterocycle and carbocycle derivatives having trka inhibitory activity

Applicant:

Shionogi & Co., Ltd., Osaka, JP;

Inventors:

Akira Yukimasa, Osaka, JP;

Kazuya Kano, Osaka, JP;

Tohru Horiguchi, Osaka, JP;

Kenichiroh Nakamura, Osaka, JP;

Motohiro Fujiu, Osaka, JP;

Hiroki Yamaguchi, Osaka, JP;

Assignee:

Shionogi & Co., Ltd., Osaka, JP;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Deepak R Rao

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 405/14 (2006.01); A61K 31/416 (2006.01); A61K 31/427 (2006.01); A61K 31/437 (2006.01); A61K 31/4375 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); C07D 401/04 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 407/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/416 (2013.01); A61K 31/427 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention provides a compound having TrkA inhibitory activity, or a pharmaceutically acceptable salt thereof. The present invention relates to a compound represented by Formula (I): wherein ═X is ═O or the like, Rand Rare hydrogen atoms or the like, -A- is —NR— or the like, B is substituted or unsubstituted aromatic carbocyclyl or the like, Ris substituted or unsubstituted alkyl or the like, Ris a hydrogen atom or the like, —W— is —CH— or the like, —W— is —CH— or the like, Ris substituted or unsubstituted aromatic carbocyclyl or the like, Ris substituted or unsubstituted aromatic heterocyclyl or the like, Ris substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

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