logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10533003 B1

PDFFull Text
Expired
Date of Patent:
Jan. 14, 2020

Filed:

Oct. 29, 2015

Polyheteroarl histone deacetylase inhibitors and their use in therapy

Applicant:

Karus Therapeutics Limited, Oxfordshire, GB;

Inventors:

Stephen Joseph Shuttleworth, Oxfordshire, GB;

Alexander Richard Liam Cecil, Oxfordshire, GB;

Somhairle MacCormick, Oxfordshire, GB;

William John Nodes, Oxfordshire, GB;

Cyrille Davy Tomassi, Oxfordshire, GB;

Franck Alexandre Silva, Oxfordshire, GB;

Assignee:

Karus Therapeutics Limited, Oxfordshire, GB;

Attorney:

Goodwin Procter LLP

Primary Examiner:

Samantha L Shterengarts

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/506 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01);
Abstract

The present invention is a compound having the following formula: or a pharmaceutically acceptable salt thereof, wherein e.g. L and Y are each independently an optionally substituted 6-membered nitrogen-containing heteroaryl; M is an optionally substituted 5- to 10-membered heteroaryl; W is a zinc-binding group; each Ris independently hydrogen or C-Calkyl; and Ris an aryl or heteroaryl. The compounds are useful as histone deacetylase (HDAC) inhibitors.

Find Patent Forward Citations

Shuttleworth, Stephen. (2020). Polyheteroarl histone deacetylase inhibitors and their use in therapy (U.S. Patent No. 10533003). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10533003

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…