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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10532977 B1

PDFFull Text
Date of Patent:
Jan. 14, 2020

Filed:

Jun. 01, 2016

Small molecule inhibitors of protein tyrosine phosphatases and uses thereof

Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

Zhong-Yin Zhang, West Lafayette, IN (US);

Rongjun He, Indianapolis, IN (US);

Assignee:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Attorney:

Faegre Baker Daniels LLP

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07C 233/05 (2006.01); C07C 309/18 (2006.01); C07C 309/24 (2006.01); A61K 45/06 (2006.01); C07C 309/17 (2006.01); A61P 25/28 (2006.01); A61P 3/10 (2006.01); A61P 31/06 (2006.01); A61P 35/00 (2006.01); C07D 211/16 (2006.01); C07D 211/18 (2006.01); C07D 215/08 (2006.01); C07D 231/40 (2006.01); C07D 233/64 (2006.01); C07D 235/10 (2006.01); C07D 235/14 (2006.01); C07D 277/46 (2006.01); C07D 277/82 (2006.01); C07D 285/135 (2006.01); C07D 307/68 (2006.01); C07D 333/20 (2006.01); A61P 35/02 (2006.01); C07D 215/38 (2006.01); C07D 233/61 (2006.01); C07D 295/135 (2006.01);
U.S. Cl.
CPC ...
C07C 309/24 (2013.01); A61K 45/06 (2013.01); A61P 3/10 (2018.01); A61P 25/28 (2018.01); A61P 31/06 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07C 309/17 (2013.01); C07C 309/18 (2013.01); C07D 211/16 (2013.01); C07D 211/18 (2013.01); C07D 215/08 (2013.01); C07D 215/38 (2013.01); C07D 231/40 (2013.01); C07D 233/61 (2013.01); C07D 233/64 (2013.01); C07D 235/10 (2013.01); C07D 235/14 (2013.01); C07D 277/46 (2013.01); C07D 277/82 (2013.01); C07D 285/135 (2013.01); C07D 295/135 (2013.01); C07D 307/68 (2013.01); C07D 333/20 (2013.01);
Abstract

Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.

Find Patent Forward Citations

Zhang, Zhong-Yin. (2020). Small molecule inhibitors of protein tyrosine phosphatases and uses thereof (U.S. Patent No. 10532977). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10532977

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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