The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 14, 2020

Filed:

Nov. 23, 2016
Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

John P. Wikswo, Brentwood, TN (US);

Dmitry A. Markov, Nashville, TN (US);

Ronald S. Reiserer, Nashville, TN (US);

Assignee:

VANDERBILT UNIVERSITY, Nashville, TN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01L 9/00 (2006.01); C12M 1/00 (2006.01); C12M 3/06 (2006.01); G01N 33/543 (2006.01); G01N 35/08 (2006.01); G01N 27/02 (2006.01); G01N 27/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01L 3/502707 (2013.01); B01L 9/00 (2013.01); C12M 23/16 (2013.01); C12M 23/34 (2013.01); C12M 29/04 (2013.01); C12M 29/10 (2013.01); G01N 27/026 (2013.01); G01N 33/54366 (2013.01); G01N 35/08 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0874 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0472 (2013.01); B01L 2400/0487 (2013.01); G01N 27/00 (2013.01);
Abstract

In certain aspects of the invention, a stackable device includes multiple elements stacked sequentially. A chamber is formed in each of the elements or between adjacent two of the elements, and each chamber is in fluid communication with an input channel and an output channel. The chambers are aligned with each other, and adjacent two chambers are separated from each other by a membrane. In certain aspects of the invention, a system includes at least one stackable device, each stackable device having multiple chambers; and at least one of a perfusion controller, a microformulator, and a microclinical analyzer in fluid communication with the at least one stackable device. In other aspects of the invention, the use of four microformulators, electrodes and an impedance analyzer can measure the impedance spectrum of each barrier in a multi-transwell plate.


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