The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Nov. 09, 2015
Interdigital Patent Holdings, Inc., Wilmington, DE (US);
Samian Kaur, Plymouth Meeting, PA (US);
Amir Helmy, Vancouver, CA;
Dimitrios Karampatsis, Ruislip, GB;
Guanzhou Wang, Brossard, CA;
Saad Ahmad, Montreal, CA;
Mahmoud Watfa, Saint Leonard, CA;
Loic Canonne-Velasquez, Verdun, CA;
InterDigital Patent Holdings, Inc., Wilmington, DE (US);
Abstract
In one aspect, a method of cell processing is disclosed, which includes disposing a plurality of cells on a substrate across which a plurality of projections are distributed and an electrically conductive layer at least partially coating said projections, exposing the cells to a cargo to be internalized by the cells, irradiating the substrate surface (and in particular the projections) with one or more laser pulses having a pulse width in a range of about 1 ns to about 1000 ns so as to facilitate uptake of the cargo by at least a portion of the cells (e.g., the cells positioned in the vicinity of the projections (e.g., within hundreds of nanometer (such as less than 100 nm) of the projections)). In some embodiments, the laser pulses have a pulse width in a range of about 10 ns to about 500 ns, e.g., in a range of about 5 ns to about 50 ns.