The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Jun. 15, 2015
Applicant:
Mission Therapeutics Limited, Cambridge, GB;
Inventors:
Assignee:
Mission Therapeutics Limited, Cambridge, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/542 (2006.01); C12Q 1/37 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
G01N 33/542 (2013.01); C12Q 1/37 (2013.01); G01N 33/569 (2013.01); G01N 2333/95 (2013.01); G01N 2500/02 (2013.01);
Abstract
The present invention relates to materials and methods for high throughput monitoring of target engagement of isopeptidases, such as deubiquitylating enzymes by, inter alia, small molecule inhibitors. In particular the invention relates to development of high throughput assays to measure isopeptidase activity in biological samples, such as cells, animal tissues, animal tumours, human tissue or patient-derived biopsies.