The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 07, 2020
Filed:
Jan. 18, 2013
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The Curators of the University of Missouri, Columbia, MO (US);
Susan L. Lindquist, Cambridge, MA (US);
Aaron D. Gitler, Philadelphia, PA (US);
Anil Cashikar, Martinez, GA (US);
Antony A. Cooper, Kansas City, MO (US);
Cole M. Haynes, New York, NY (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The Curators of the University of Missouri, Columbia, MO (US);
Abstract
Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.