The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 07, 2020

Filed:

Jul. 12, 2017
Applicant:

Sirna Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Guillaume Chorn, San Francisco, CA (US);

Lee Lim, San Francisco, CA (US);

Lihong Zhao, Walnut Creek, CA (US);

Assignee:

SIRNA THERAPEUTICS, INC., Cambridge, MA (US);

Attorney:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 15/1138 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/33 (2013.01); C12N 2310/332 (2013.01); C12N 2310/3517 (2013.01); C12N 2310/533 (2013.01); C12N 2320/51 (2013.01); C12N 2320/52 (2013.01);
Abstract

This invention relates generally to segmented oligonucleotides capable of modulating gene expression. Specifically, the instant invention relates to segmented microRNA (miRNA) oligonucleotides, including segmented miRNA precursors and segmented pre-microRNAs. The invention also relates to compositions comprising such segmented oligonucleotides, as well as to methods of making and using such oligonucleotides for diagnosis and treatment of diseases associated or causally linked to aberrant levels or activities of gene expression, including aberrant levels of coding and/or non-coding RNA.


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